Publications

PCTS Model Dissemination 

Papers: 

Gilbert, T.M., Randle, L., Quinn, M., McGreevy, O., O’Leary, L., Young, R., Diaz-Neito, R., Jones, R.P., Greenhalf, B., Goldring, C., Fenwick, S. Malik, H. and Palmer, D. Molecular biology of cholangiocarcinoma and its implications for targeted therapy in patient management. EJSO. Article in press https://doi.org/10.1016/j.ejso.2024.108352 *Joint first author

McGreevy, O., Bosakhar, M. Gilbert, T., Quinn, M., Fenwick, S. Malik, H., Goldring, C., and Randle, L. 2024. The importance of preclinical models in cholangiocarcinoma. EJSO, Article in press 108304. https://doi.org/10.1016/j.ejso.2024.108304

Chidlow, S.J., Randle, L.E. and Kelly, R.A (2022) Predicting physiologically-relevant oxygen concentrations in precision-cut liver slices using mathematical modelling. . PloS one, 17(11), p.e0275788.https://doi.org/10.1371/journal.pone.0275788 *Joint last author.

Kelly RA, Leedale J, Harrell A, Beard DA, Randle LE, Chadwick AE, Webb SD. Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture. PLoS ONE, 13 :e0207803-e0207803 

Del Casino A, Valentina L, Rakesh B, Randle LE, Dascombe MJ, Fennell DBJ, Drew MGB, Angus B, Fielding AJ, Ismail FMD. 2018. Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials ChemistrySelect, 3 :7572-7580 

Fielding AJ, Evans PG, Alizadeh S, Bisby R, Drew MGB, Del Casino A, Dunn JF, Randle LE, Dempster NM, Nahar L, Sarker SD, Cantú Reinhard FG, de Visser SP, Dascombe MJ, Ismail FMD. 2017. Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines Chemistry - A European Journal, 

Eakins R, Walsh J, Randle L, Jenkins RE, Schuppe-Koistinen I, Rowe C, Lewis PS, Vasieva O, Prats N, Brillant N, Auli M, Bayliss M, Webb S, Rees JA, Kitteringham NR, Goldring CE, Park BK. 2015. Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome SCIENTIFIC REPORTS, 5, 16423. *Joint first author  https://doi.org/10.1038/srep16423

Stachulski AV, Baillie TA, Kevin Park B, Scott Obach R, Dalvie DK, Williams DP, Srivastava A, Regan SL, Antoine DJ, Goldring CEP, Chia AJL, Kitteringham NR, Randle LE, Callan H, Castrejon JL, Farrell J, Naisbitt DJ, Lennard MS. 2013. The generation, detection, and effects of reactive drug metabolites Medicinal Research Reviews, 33 :985-1080 >DOI

Kitteringham, N.R., Abdullah, A., Walsh, J., Randle, L., Jenkins, R.E., Sison, R., Goldring, C.E., Powell, H., Sanderson, C., Williams, S., Higgins, L., Yamamoto, M., Hayes, J. and Park, B.K. (2010). Proteomic Analysis Of Nrf2 Deficient Transgenic Mice Reveals Cellular Defence And Lipid Metabolism As Primary Nrf2-Dependent Pathways In The Liver. J. Proteomics, 73(8):1612-31.

Copple, I.M., Goldring, C.E., Jenkins, R.E., Chia, A.J., Randle, L.E., Hayes, J.D., Kitteringham, N.R. and Park, B.K. (2008). The Hepatotoxic Metabolite Of Acetaminophen Directly Activates The Keap1-Nrf2 Cell Defence System. Hepatology, 48(4):1292-301.

Randle LE, Goldring CE, Benson CA, Metcalfe PN, Kitteringham NR, Park BK, Williams DP (2008). Investigation Of The Effect Of A Panel Of Model Hepatotoxins On The Nrf2-Keap1 Defence Response Pathway In CD-1 Mice. Toxicology. 243(3):249-60.

Randle LE, Sathish JG, Kitteringham NR, Macdonald I, Williams DP, Park BK. (2008) alpha(1)-Adrenoceptor Antagonists Prevent Paracetamol-Induced Hepatotoxicity In Mice. Br. J. Pharmacol. 153(4):820-30.

Williams DP, Antoine DJ, Butler PJ, Jones R, Randle L, Payne A, Howard M, Gardner I, Blagg J, Park BK (2007). The Metabolism And Toxicity Of Furosemide In The Wistar Rat And CD-1 Mouse: A Chemical And Biochemical Definition Of The Toxicophore. J. Pharmacol. Exp. Ther. Sep;322(3):1208-20.

Goldring, C.E., Kitteringham, N.R., Jenkins, R., Lovatt, C.A., Randle, L.E., Abdullah, A., Owen, A., Liu, X., Butler, P.J., Williams, D.P., Metcalfe, P., Berens, C., Hillen, W., Foster, B., Simpson, A., McLellan, L., & Park, B.K. (2006). Development Of A Transactivator In Hepatoma Cells That Allows Expression Of Phase I, Phase II, And Chemical Defence Genes. Am. J. Physiol. Cell Physiol. 290 (1), C104-15.

Goldring, C.E., Kitteringham, N.R., Elsby, R., Randle, L.E., Clement, Y.N., Williams, D.P., Mcmahon, M., Hayes, J.D., Itoh, K., Yamamoto, M. & Park, B.K. (2004). Activation Of Hepatic Nrf2 In Vivo By Acetaminophen In CD-1 Mice. Hepatology, 39, 1267-76.

O'Neill, P.M., Mukhtar, A., Stocks, P.A., Randle, L.E., Hindley, S., Ward, S.A., Storr, R.C., Bickley, J.F., O'Neil, I.A., Maggs, J.L., Hughes, R.H., Winstanley, P.A., Bray, P.G. & Park, B.K. (2003). Isoquine And Related Amodiaquine Analogues: A New Generation Of Improved 4-Aminoquinoline Antimalarials. J Med. Chem, 46, 4933-45.

Abstracts presented at Scientific Conferences: 

Gilbert, T, Randle, L, Diaz-Neito, R, Jones, R, Fenwick, S, Goldring, C and Malik, H. Developing a patient-derived model of cholangiocarcinoma using Precision Cut Tissue Slices (PCTS).  15th Biennial Congress of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA). Lyon, France 6-9 June 2023.  PBB-003  https://doi.org/10.1016/j.hpb.2023.07.659

Gilbert, T., Randle, L., Diaz-Neito, R., Jones, R., Fenwick, S., Goldring, C and Malik, H. (2022). Developing a patient-derived model of cholangiocarcinoma using Precision Cut Tissue Slices (PCTS). AUGIS 2022 Meeting, Aberdeen. British Journal of Surgery, Volume 109, Issue Supplement_9, December 2022, znac404.020, https://doi.org/10.1093/bjs/znac404.020

Ismail, F. M. D., Morris, H., Dempster, N.M., Saleem, I.Y., Randle, L.E., Kasaija, F., Alizadeh-Shekalgourabi, S., Evans, P.G., Dascombe, M.J. Drew, M.G. and Edwards, G (2011). Deducing The Definitive Geometry Of Chloroquine-Haematin Interactions Using Mass Spectrometry And DFT Investigations. BMSS Meeting 2011. 

Goldring, C.E., Randle, L.E., Sison, R., Kitteringham, N.R., Denk, D., Jenkins, R.E., Walsh, J., Lane, B., Kipar, A.J., and Park, B.K. (2011). A Biochemical And Proteomic Analysis Of The Effect Of Nrf2 Gene Deletion On Acute Acetaminophen-Induced Hepatotoxicity. Tox. Sci., 120 (Supp 2), 535, Abstract 2500, SOT 2011 Annual Meeting, Washington.

Chia, A.,  Megherbi, R., Copple,I., Kitteringham, N.R., Randle, L.E., Goldirng, C. E., and Park, B.K. (2011). Activation of Nrf2 by intrinsic and extrinsic ligands. Tox. Sci., 120 (Supp 2), 535, Abstract 2498, SOT 2011 Annual Meeting, Washington. 

Starkey Lewis, P.J., Goldring, C.E., Platt, V., Obeng, A.M., Randle, L., Rowe, C., Moggs, J., and Park, K. (2011). Profiling The Hepatic Proteome To Explore The Molecular Basis Of The Chronotoxicity Of Acetaminophen. Tox. Sci., 120 (Supp 2), 95, Abstract 446, SOT 2011 Annual Meeting, Washington. 

Yeang, H. X. Aw., Hamdam, J., Al-Huseini, L., Goodwin, C., Randle, L., Melendez, A., Park, K., Goldring, C., and Sathish, J., (2010). The Transcription Factor Nrf2 Affects Dendritic Cell Maturation And Phagocytic Function. Immunol. 131 (Supp 1), 107. BSI Annual Congress 2010. 

Randle, L.E., Goldring, C.E., Jenkins, R.E., Denk, D., Antoine, D.J., Sison, R.L., Williams, D.P., Hayes, J.D., Kitteringham, N.R., Park, B.K. (2011). A Biochemical, Toxicological And Proteomic Analysis Investgating The Effect Of Nrf2 Gene Deletion On Paraceatmol-Induced Hepatotoxicity In Vivo. Drug Metab. Rev., 41 (Supp 1), 23-24, Abstract 57, 11th European ISSX Conference 2009, Lisbon. 

Goldring, C,E., Copple, I., Jenkins, R., Randle, L., Chia, A., Hayes J., Kitteringham, N., and Park, K., (2008). Activation Of The Keap1-Nrf2-ARE Cell Defense System By The Reactive Metabolite Of Acetaminophen. Drug Metab. Rev., 40 (Supp 1), 95-96, Abstract 138, 10th European ISSX Conference 2008, Vienna. 

Randle, L.E., Goldring, C.E., Kitteringham, N.R., Benson, C, Metcalf, P, Park BK and Williams DP (2007) Investigation Of The Effect Of A Panel Of Model Hepatotoxins On The Nrf2-Keap1 Defence Response Pathway In CD-1 Mice. BTS Autumn Meeting, Aberdeen.

Randle, L.E., Goldring, C.E., Williams, D.P., & Park, B.K (2006). Mechanism Of Defence During Chemical Induced Hepatotoxicity. Drug Metab. Rev., 38 (Supp 1), 56-58, Abstract 70, 9th European ISSX Conference 2006, Manchester. 

Goldring, C.E., Kitteringham, N.R., Lovatt, C.A., Jenkins, R., Randle, L.E., Abdullah, A., Owen, A., Liu, X., Berens, C., Hillen, W., & Park, B.K. (2005). Development Of Doxycycline-Regulatable Gene Expression In Hepatoma Cells. Toxicol., 213, 262-263, Joint BTS/BPS Meeting 2004, Liverpool. 

Butler, P.J., Randle, L.E., Jones, R., Macrae, P., Blagg, J., Smith, D.A., Williams, D.P. & Park, B.K. (2004). The Role Of Metabolism In Furosemide Toxicity. Toxicol., 202, 98-99. BTS Winter Meeting 2004

Randle, L.E., Greenough, C.L., Williams, D.P., Clement, Y.N., Kitteringham, N.R., Elsby, R. & Park, B.K. (2004). Paracetamol-Induced Hepatotoxicity: Protection By Alpha (1)-Antagonists. Toxicol., 194, 238-239. BTS Winter Meeting 2003, Edinburgh.  Update in BTS Newsletter Summer 2004.

Williams, D.P., O'Donnell, C., Randle, L.E., Goldring, C.E., Garcia-Allen, C., Johnston, G., Kitteringham, N.R., Pirmohammed, M., Smith, D.A. & Park, B.K. (2003). Transcription Factor Regulation And Gene Expression In Response To The Antipsychotic, Clozapine. Brit. J. Clin. Pharmacol., 55, 446. BPS Meeting 2003